| Reaction Details |
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 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
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| Ligand | BDBM75031 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
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| EC50 | 228100±n/a nM |
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| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Importin subunit alpha-1 |
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| Name: | Importin subunit alpha-1 |
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| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57852.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_119609447 |
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| Residue: | 529 |
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| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
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| BDBM75031 |
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| n/a |
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| Name | BDBM75031 |
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| Synonyms: | (3Z)-3-[(2,6-dimethylanilino)-hydroxy-methylene]-2,2-diketo-1-methyl-thieno[3,2-c]thiazin-4-one | (3Z)-3-[(2,6-dimethylanilino)-hydroxymethylidene]-1-methyl-2,2-dioxo-4-thieno[3,2-c]thiazinone | (3Z)-3-[(2,6-dimethylanilino)-hydroxymethylidene]-1-methyl-2,2-dioxothieno[3,2-c]thiazin-4-one | (3Z)-3-[[(2,6-dimethylphenyl)amino]-oxidanyl-methylidene]-1-methyl-2,2-bis(oxidanylidene)thieno[3,2-c][1,2]thiazin-4-one | MLS000755233 | N-(2,6-dimethylphenyl)-4-hydroxy-1-methyl-2,2-dioxo-1,2-dihydro-2lambda~6~-thieno[3,2-c][1,2]thiazine-3-carboxamide | SMR000338102 | cid_5523942 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N2O4S2 |
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| Mol. Mass. | 364.439 |
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| SMILES | CN1c2ccsc2C(=O)C(C(=O)Nc2c(C)cccc2C)S1(=O)=O |
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| Structure | 
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