| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
|---|
| Ligand | BDBM75036 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
|---|
| EC50 | 44170±n/a nM |
|---|
| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Importin subunit alpha-1 |
|---|
| Name: | Importin subunit alpha-1 |
|---|
| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 57852.15 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_119609447 |
|---|
| Residue: | 529 |
|---|
| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
|
|
|
|---|
| BDBM75036 |
|---|
| n/a |
|---|
| Name | BDBM75036 |
|---|
| Synonyms: | (E)-2-cyano-3-[1-[2-(2-furanylmethylamino)-2-oxoethyl]-3-indolyl]-N-(2-methoxyethyl)-2-propenamide | (E)-2-cyano-3-[1-[2-(2-furfurylamino)-2-keto-ethyl]indol-3-yl]-N-(2-methoxyethyl)acrylamide | (E)-2-cyano-3-[1-[2-(furan-2-ylmethylamino)-2-oxidanylidene-ethyl]indol-3-yl]-N-(2-methoxyethyl)prop-2-enamide | (E)-2-cyano-3-[1-[2-(furan-2-ylmethylamino)-2-oxoethyl]indol-3-yl]-N-(2-methoxyethyl)prop-2-enamide | MLS000711505 | SMR000281272 | cid_5767037 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H22N4O4 |
|---|
| Mol. Mass. | 406.4345 |
|---|
| SMILES | COCCNC(=O)C(=C\c1cn(CC(=O)NCc2ccco2)c2ccccc12)\C#N |
|---|
| Structure | 
|
|---|
Search and Browse
