Ki Summary

Reaction Details

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Target

Intestinal-type alkaline phosphatase 1

Ligand

BDBM39617

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay

IC50

1530±n/a nM

Citation

PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Intestinal-type alkaline phosphatase 1

Name:

Intestinal-type alkaline phosphatase 1

Synonyms:

Alpi | PPBI1_RAT

Type:

Enzyme Catalytic Domain

Mol. Mass.:

58396.39

Organism:

Rattus norvegicus (Rat)

Description:

P15693

Residue:

540

Sequence:

MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFL
GDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYL
CGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTY
AHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGD
SDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNR
NASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEK
ASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYV
LNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAH
VMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS

BDBM39617

n/a

Name

BDBM39617

Synonyms:

3-[5-(methylamino)-1,3,4-thiadiazol-2-yl]-1-benzopyran-2-one | 3-[5-(methylamino)-1,3,4-thiadiazol-2-yl]-2H-chromen-2-one | 3-[5-(methylamino)-1,3,4-thiadiazol-2-yl]chromen-2-one | 3-[5-(methylamino)-1,3,4-thiadiazol-2-yl]coumarin | MLS000094728 | SMR000030281 | cid_3244772

Type

Small organic molecule

Emp. Form.

C12H9N3O2S

Mol. Mass.

259.284

SMILES

CNc1nnc(s1)-c1cc2ccccc2oc1=O

Structure