Ki Summary

Reaction Details

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Target

Mitochondrial import inner membrane translocase subunit TIM10

Ligand

BDBM67804

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay

IC50

6120±n/a nM

Citation

PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Mitochondrial import inner membrane translocase subunit TIM10

Name:

Mitochondrial import inner membrane translocase subunit TIM10

Synonyms:

MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...

Type:

Enzyme Catalytic Domain

Mol. Mass.:

10303.50

Organism:

Saccharomyces cerevisiae S288c

Description:

gi_285809906

Residue:

Sequence:

MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESS
CLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF

BDBM67804

n/a

Name

BDBM67804

Synonyms:

(4,5-dibromo-6-oxopyridazin-1-yl)methyl 2-chlorobenzoate | 2-chlorobenzoic acid (4,5-dibromo-6-keto-pyridazin-1-yl)methyl ester | 2-chlorobenzoic acid (4,5-dibromo-6-oxo-1-pyridazinyl)methyl ester | MLS000541286 | SMR000126144 | [4,5-bis(bromanyl)-6-oxidanylidene-pyridazin-1-yl]methyl 2-chloranylbenzoate | [4,5-dibromo-6-oxo-1(6H)-pyridazinyl]methyl 2-chlorobenzenecarboxylate | cid_1474487

Type

Small organic molecule

Emp. Form.

C12H7Br2ClN2O3

Mol. Mass.

422.457

SMILES

Clc1ccccc1C(=O)OCn1ncc(Br)c(Br)c1=O

Structure