Ki Summary

Reaction Details

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Target

Mitochondrial import inner membrane translocase subunit TIM10

Ligand

BDBM78318

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay

IC50

8190±n/a nM

Citation

PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Mitochondrial import inner membrane translocase subunit TIM10

Name:

Mitochondrial import inner membrane translocase subunit TIM10

Synonyms:

MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...

Type:

Enzyme Catalytic Domain

Mol. Mass.:

10303.50

Organism:

Saccharomyces cerevisiae S288c

Description:

gi_285809906

Residue:

Sequence:

MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESS
CLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF

BDBM78318

n/a

Name

BDBM78318

Synonyms:

(E)-2-butenedioic acid O1-ethyl ester O4-[2-(4-nitroanilino)-2-oxoethyl] ester | (E)-but-2-enedioic acid O1-ethyl ester O4-[2-keto-2-(4-nitroanilino)ethyl] ester | 1-O-ethyl 4-O-[2-(4-nitroanilino)-2-oxoethyl] (E)-but-2-enedioate | MLS000516612 | O1-ethyl O4-[2-[(4-nitrophenyl)amino]-2-oxidanylidene-ethyl] (E)-but-2-enedioate | SMR000342718 | cid_6393890

Type

Small organic molecule

Emp. Form.

C14H14N2O7

Mol. Mass.

322.2702

SMILES

CCOC(=O)\C=C\C(=O)OCC(=O)Nc1ccc(cc1)[N+]([O-])=O

Structure