Ki Summary

Reaction Details

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Target

Ubiquitin-conjugating enzyme E2 N

Ligand

BDBM67694

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm

IC50

2281±80 nM

Citation

PubChem, PC Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Ubiquitin-conjugating enzyme E2 N

Name:

Ubiquitin-conjugating enzyme E2 N

Synonyms:

BLU | UBE2N | UBE2N_HUMAN | ubiquitin-conjugating enzyme E2 N

Type:

PROTEIN

Mol. Mass.:

17137.61

Organism:

Homo sapiens (Human)

Description:

EBI_101440

Residue:

152

Sequence:

MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPE
EYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDP
LANDVAEQWKTNEAQAIETARAWTRLYAMNNI

BDBM67694

n/a

Name

BDBM67694

Synonyms:

MLS002232301 | N'-[4-[[5-[3-[[(E)-4-(dimethylamino)-1-oxobut-2-enyl]amino]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-3-fluorophenyl]-N-(4-fluorophenyl)propanediamide | N'-[4-[[5-[3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-3-fluoranyl-phenyl]-N-(4-fluorophenyl)propanediamide | N'-[4-[[5-[3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-3-fluoro-phenyl]-N-(4-fluorophenyl)malonamide | N'-[4-[[5-[3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-3-fluorophenyl]-N-(4-fluorophenyl)propanediamide | SMR001307855 | cid_42601361

Type

Small organic molecule

Emp. Form.

C33H29F2N7O4

Mol. Mass.

625.6247

SMILES

CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1c[nH]c2ncnc(Oc3ccc(NC(=O)CC(=O)Nc4ccc(F)cc4)cc3F)c12

Structure