Ki Summary

Reaction Details

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Target

Tropomyosin alpha-1 chain

Ligand

BDBM50870

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)

EC50

8319±n/a nM

Citation

PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Tropomyosin alpha-1 chain

Name:

Tropomyosin alpha-1 chain

Synonyms:

TPM1 | TPM1_PIG | cardiac alpha tropomyosin

Type:

Enzyme Catalytic Domain

Mol. Mass.:

32681.01

Organism:

Sus scrofa

Description:

P42639

Residue:

284

Sequence:

MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKY
SEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA
DESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAE
ERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAE
FAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI

BDBM50870

n/a

Name

BDBM50870

Synonyms:

(8R,8aR)-6-Amino-8-furan-3-yl-2-methyl-2,3,8,8a-tetrahydro-1H-isoquinoline-5,7,7-tricarbonitrile | (8R,8aR)-6-amino-8-(3-furanyl)-2-methyl-1,3,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrile;ethanol | (8R,8aR)-6-amino-8-(3-furyl)-2-methyl-1,3,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrile;ethanol | (8R,8aR)-6-amino-8-(furan-3-yl)-2-methyl-1,3,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrile;ethanol | (8R,8aR)-6-azanyl-8-(furan-3-yl)-2-methyl-1,3,8,8a-tetrahydroisoquinoline-5,7,7-tricarbonitrile;ethanol | MLS000552641 | SMR000146156 | cid_9550040

Type

Small organic molecule

Emp. Form.

C17H15N5O

Mol. Mass.

305.3339

SMILES

CN1CCC2=C(C#N)C(=N)C(C#N)(C#N)[C@@H]([C@H]2C1)c1ccoc1 |c:4|

Structure