Ki Summary

Reaction Details

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Target

Orexin/Hypocretin receptor type 1

Ligand

BDBM79944

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1)

IC50

3096±n/a nM

Citation

PubChem, PC Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Orexin/Hypocretin receptor type 1

Name:

Orexin/Hypocretin receptor type 1

Synonyms:

Type:

Protein

Mol. Mass.:

47554.50

Organism:

Homo sapiens (Human)

Description:

O43613

Residue:

425

Sequence:

MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP

BDBM79944

n/a

Name

BDBM79944

Synonyms:

MLS001080195 | N-[2-[(5Z)-2,4-bis(oxidanylidene)-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-3-yl]ethyl]-1-(3-methylsulfanylphenyl)-5-oxidanylidene-pyrrolidine-3-carboxamide | N-[2-[(5Z)-2,4-diketo-5-(3-pyridylmethylene)thiazolidin-3-yl]ethyl]-5-keto-1-[3-(methylthio)phenyl]pyrrolidine-3-carboxamide | N-[2-[(5Z)-2,4-dioxo-5-(3-pyridinylmethylidene)-3-thiazolidinyl]ethyl]-1-[3-(methylthio)phenyl]-5-oxo-3-pyrrolidinecarboxamide | N-[2-[(5Z)-2,4-dioxo-5-(pyridin-3-ylmethylidene)-1,3-thiazolidin-3-yl]ethyl]-1-(3-methylsulfanylphenyl)-5-oxopyrrolidine-3-carboxamide | SMR000717597 | cid_24979400

Type

Small organic molecule

Emp. Form.

C23H22N4O4S2

Mol. Mass.

482.575

SMILES

CSc1cccc(c1)N1CC(CC1=O)C(=O)NCCN1C(=O)S\C(=C/c2cccnc2)C1=O

Structure