| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin alpha-1A chain |
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| Ligand | BDBM81745 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Activity Assay |
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| IC50 | >5.0e+4± 7e+3 nM |
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| Citation |  Morgan, RE; Ahn, S; Nzimiro, S; Fotie, J; Phelps, MA; Cotrill, J; Yakovich, AJ; Sackett, DL; Dalton, JT; Werbovetz, KA Inhibitors of tubulin assembly identified through screening a compound library. Chem Biol Drug Des72:513-24 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin alpha-1A chain |
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| Name: | Tubulin alpha-1A chain |
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| Synonyms: | TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain |
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| Type: | Protein |
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| Mol. Mass.: | 50049.25 |
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| Organism: | Sus scrofa (Pig) |
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| Description: | P02550 |
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| Residue: | 451 |
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| Sequence: | MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY
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| BDBM81745 |
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| n/a |
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| Name | BDBM81745 |
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| Synonyms: | Oryzalin Analogue, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N4O2S |
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| Mol. Mass. | 382.479 |
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| SMILES | CCCN(CCC)c1c(cc(cc1C#N)S(=O)(=O)Nc1ccccc1)C#N |
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| Structure | 
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