Ki Summary

Reaction Details

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Target

Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase

Ligand

BDBM81037

Substrate/Competitor

n/a

Meas. Tech.

Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase

IC50

48400±n/a nM

Citation

PubChem, PC Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Assay Method

Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase

Name:

Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase

Synonyms:

n/a

Type:

Enzyme Catalytic Domain

Mol. Mass.:

109731.64

Organism:

Plasmodium falciparum 3D7

Description:

gi_12381848

Residue:

950

Sequence:

MEYETSLKCLDEIRCVNNVKYMETEDLTDFNKKSAYYICKEIYEKQLSNENGYVVIGLSG
GKTPIDVYKNMCAIKDIKIDKNKLIFFIIDERYKNDDHKFSNYNNIKFLFDELNINKETQ
LYKPDTKKDLVSCIRDYNEQIKSMIEKYKKIDIVILGMGSDFHIASLFPNVYYNIYMNNY
QNNYIYEDNETIRSLNADNNVNLSLLNEQVYFTTTNNFDVRKRITVSLNLLSNSTSKIFL
LNTADKLNLWKNMLLNFYVNPNYNLYPAFKMIDSSNTTVIACGHKNYSKMLEDLYVQKDE
ALSPISNNNVENKNELLTIVIFGCSGDLAKKKIYPALFKLFCNNLLPKNIIIIGFARTGQ
DFESFFNKIAIYLKISLNSYKNLSVFEKAERLNSFKSKCRYFIGNYLSPESFENFDVYIT
QEERIALGCCGQKGNEKHKQVNVTSQFPNNHTSINIINNIDNGCESPMLTDSPKRYPCSS
SYSSTSGTAVCPYSSQHDVKPSNNGCPYLSSQANTSDSSGCPYISYHTNKSGHLGCPYTI
TRMLYLALPPHVFVSTLQNYKKYCLNKNRINKILLEKPFGKDLESFKILSKQILETFPEK
NIYRIDHYLGKDMVSGLLKLKFTNIFLLSLMNRHFIKCIKITLKETKGVYGRGQYFDPYG
IIRDVMQNHMLQLLALITMEHPTDLNDKSIQNEKIKILKSIASIKLEDTVIGQYVKSNND
DTNNNINSNISENASIDKSKINHSYHDDPHVDPNSITPTFCACVLYINSINWHGVPIILK
AGKGLNNDICEIKIQFHNIMGSSDESMYNNEFVIILQPVEGIYLKLMIKKMGSEEMEEVQ
LNLSLNENNNKAYVPEAYETLLSECYKGYKRKFISDEELYESWRIFTPLLNELQEKHIKP
LSYPFGSSGPQEAYDLVRKYYNYGKNYATTAKFCRKSSYYDDSLFDNMRE

BDBM81037

n/a

Name

BDBM81037

Synonyms:

2-(4-nitrophenyl)-2-oxoethyl N-(4-methylbenzoyl)glycylglycinate | 2-[[2-(p-toluoylamino)acetyl]amino]acetic acid [2-keto-2-(4-nitrophenyl)ethyl] ester | 2-[[2-[[(4-methylphenyl)-oxomethyl]amino]-1-oxoethyl]amino]acetic acid [2-(4-nitrophenyl)-2-oxoethyl] ester | MLS000576419 | SMR000197088 | [2-(4-nitrophenyl)-2-oxidanylidene-ethyl] 2-[2-[(4-methylphenyl)carbonylamino]ethanoylamino]ethanoate | [2-(4-nitrophenyl)-2-oxoethyl] 2-[[2-[(4-methylbenzoyl)amino]acetyl]amino]acetate | cid_2300528

Type

Small organic molecule

Emp. Form.

C20H19N3O7

Mol. Mass.

413.3808

SMILES

Cc1ccc(cc1)C(=O)NCC(=O)NCC(=O)OCC(=O)c1ccc(cc1)[N+]([O-])=O

Structure