| Reaction Details |
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 | Report a problem with these data |
| Target | Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
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| Ligand | BDBM34737 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase |
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| IC50 | 24800±n/a nM |
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| Citation |  PubChem, PC Dose Response orthogonal assay utilizing the direct end-point detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
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| Name: | Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
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| Synonyms: | n/a |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 109731.64 |
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| Organism: | Plasmodium falciparum 3D7 |
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| Description: | gi_12381848 |
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| Residue: | 950 |
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| Sequence: | MEYETSLKCLDEIRCVNNVKYMETEDLTDFNKKSAYYICKEIYEKQLSNENGYVVIGLSG
GKTPIDVYKNMCAIKDIKIDKNKLIFFIIDERYKNDDHKFSNYNNIKFLFDELNINKETQ
LYKPDTKKDLVSCIRDYNEQIKSMIEKYKKIDIVILGMGSDFHIASLFPNVYYNIYMNNY
QNNYIYEDNETIRSLNADNNVNLSLLNEQVYFTTTNNFDVRKRITVSLNLLSNSTSKIFL
LNTADKLNLWKNMLLNFYVNPNYNLYPAFKMIDSSNTTVIACGHKNYSKMLEDLYVQKDE
ALSPISNNNVENKNELLTIVIFGCSGDLAKKKIYPALFKLFCNNLLPKNIIIIGFARTGQ
DFESFFNKIAIYLKISLNSYKNLSVFEKAERLNSFKSKCRYFIGNYLSPESFENFDVYIT
QEERIALGCCGQKGNEKHKQVNVTSQFPNNHTSINIINNIDNGCESPMLTDSPKRYPCSS
SYSSTSGTAVCPYSSQHDVKPSNNGCPYLSSQANTSDSSGCPYISYHTNKSGHLGCPYTI
TRMLYLALPPHVFVSTLQNYKKYCLNKNRINKILLEKPFGKDLESFKILSKQILETFPEK
NIYRIDHYLGKDMVSGLLKLKFTNIFLLSLMNRHFIKCIKITLKETKGVYGRGQYFDPYG
IIRDVMQNHMLQLLALITMEHPTDLNDKSIQNEKIKILKSIASIKLEDTVIGQYVKSNND
DTNNNINSNISENASIDKSKINHSYHDDPHVDPNSITPTFCACVLYINSINWHGVPIILK
AGKGLNNDICEIKIQFHNIMGSSDESMYNNEFVIILQPVEGIYLKLMIKKMGSEEMEEVQ
LNLSLNENNNKAYVPEAYETLLSECYKGYKRKFISDEELYESWRIFTPLLNELQEKHIKP
LSYPFGSSGPQEAYDLVRKYYNYGKNYATTAKFCRKSSYYDDSLFDNMRE
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| BDBM34737 |
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| n/a |
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| Name | BDBM34737 |
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| Synonyms: | 2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one | 2-(4-methylphenyl)-1,2-benzothiazol-3-one | 2-(p-tolyl)-1,2-benzothiazol-3-one | MLS000583746 | SMR000200989 | acs.jmedchem.1c00409_ST.174 | cid_935415 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11NOS |
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| Mol. Mass. | 241.308 |
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| SMILES | Cc1ccc(cc1)-n1sc2ccccc2c1=O |
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| Structure | 
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