Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Apelin receptor |
---|
Ligand | BDBM70650 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay |
---|
IC50 | >66600±n/a nM |
---|
Citation | PubChem, PC SAR analysis counterscreen of small molecule antagonists of the CCR6 receptor using an APJ receptor luminescent beta-arrestin assay PubChem Bioassay(2011)[AID] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Apelin receptor |
---|
Name: | Apelin receptor |
Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 42664.06 |
Organism: | Homo sapiens (Human) |
Description: | P35414 |
Residue: | 380 |
Sequence: | MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD
|
|
|
BDBM70650 |
---|
n/a |
---|
Name | BDBM70650 |
Synonyms: | 2-[(4-chlorobenzyl)sulfanyl]-6-methyl-4-(2-thienyl)-5,6,7,8-tetrahydro[1,6]naphthyridine-3-carbonitrile | 2-[(4-chlorobenzyl)thio]-6-methyl-4-(2-thienyl)-7,8-dihydro-5H-1,6-naphthyridine-3-carbonitrile | 2-[(4-chlorophenyl)methylsulfanyl]-6-methyl-4-thiophen-2-yl-7,8-dihydro-5H-1,6-naphthyridine-3-carbonitrile | 2-[(4-chlorophenyl)methylthio]-6-methyl-4-thiophen-2-yl-7,8-dihydro-5H-1,6-naphthyridine-3-carbonitrile | MLS000545076 | SMR000160396 | cid_1201889 |
Type | Small organic molecule |
Emp. Form. | C21H18ClN3S2 |
Mol. Mass. | 411.971 |
SMILES | CN1CCc2nc(SCc3ccc(Cl)cc3)c(C#N)c(-c3cccs3)c2C1 |
Structure |
|