Ki Summary

Reaction Details

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Target

Phospholipase A2

Ligand

BDBM57574

Substrate/Competitor

n/a

Meas. Tech.

Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay

IC50

975±n/a nM

Citation

PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Assay Method

Phospholipase A2

Name:

Phospholipase A2

Synonyms:

Type:

Protein

Mol. Mass.:

16364.13

Organism:

Homo sapiens (Human)

Description:

P04054

Residue:

148

Sequence:

MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPV
DELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNC
DRNAAICFSKAPYNKAHKNLDTKKYCQS

BDBM57574

n/a

Name

BDBM57574

Synonyms:

(6E)-5-azanylidene-6-[[2,5-dimethyl-1-(3-methylphenyl)pyrrol-3-yl]methylidene]-2-pentan-3-yl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | (6E)-6-[[2,5-dimethyl-1-(3-methylphenyl)-3-pyrrolyl]methylidene]-5-imino-2-pentan-3-yl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | (6E)-6-[[2,5-dimethyl-1-(3-methylphenyl)pyrrol-3-yl]methylidene]-5-imino-2-pentan-3-yl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | (6E)-6-[[2,5-dimethyl-1-(m-tolyl)pyrrol-3-yl]methylene]-2-(1-ethylpropyl)-5-imino-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | 6-[1-(2,5-Dimethyl-1-m-tolyl-1H-pyrrol-3-yl)-meth-(E)-ylidene]-2-(1-ethyl-propyl)-5-imino-5,6-dihydro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | MLS000588584 | SMR000220031 | cid_6300247

Type

Small organic molecule

Emp. Form.

C24H27N5OS

Mol. Mass.

433.569

SMILES

CCC(CC)C1=NN2C(S1)=NC(=O)\C(=C\c1cc(C)n(c1C)-c1cccc(C)c1)C2=N |c:10,t:5|

Structure