Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Bromodomain-containing protein 2 [60-463] |
---|
Ligand | BDBM274292 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | TR-FRET In-Vitro Binding Assay |
---|
pH | 7.5±n/a |
---|
IC50 | 15.0±n/a nM |
---|
Comments | extracted |
---|
Citation | Rueger, H; Blank, J; Bordas, V; Cotesta, S; Bold, G; Guagnano, V; Vaupel, A Pyrrolopyrrolone derivatives and their use as BET inhibitors US Patent US9550796 Publication Date 1/24/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Bromodomain-containing protein 2 [60-463] |
---|
Name: | Bromodomain-containing protein 2 [60-463] |
Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain-containing protein 2 | KIAA9001 | RING3 |
Type: | Enzyme Catalytic Domain (aa 60-463) |
Mol. Mass.: | 45228.55 |
Organism: | Homo sapiens (Human) |
Description: | P25440[60-463] |
Residue: | 404 |
Sequence: | NPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQ
PMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVAS
MPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLN
IPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSP
ASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKE
LLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVR
LMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPL
|
|
|
BDBM274292 |
---|
n/a |
---|
Name | BDBM274292 |
Synonyms: | 6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)-N,1-dimethyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrole-3-carboxamide | US9550796, Example 93 |
Type | Small organic molecule |
Emp. Form. | C22H20ClN7O2 |
Mol. Mass. | 449.893 |
SMILES | CNC(=O)c1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnn(C)c2n1)c1ccc(Cl)cc1 |
Structure |
|