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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | CREB-binding protein | ||
| Ligand | BDBM274323 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Assay for CREB protein | ||
| pH | 7.5±n/a | ||
| Temperature | 303.15±n/a K | ||
| IC50 | 1500±n/a nM | ||
| Comments | extracted | ||
| Citation |  Rueger, H; Blank, J; Bordas, V; Cotesta, S; Bold, G; Guagnano, V; Vaupel, A Pyrrolopyrrolone derivatives and their use as BET inhibitors US Patent US9550796 Publication Date 1/24/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| CREB-binding protein | |||
| Name: | CREB-binding protein | ||
| Synonyms: | CBP | CBP_HUMAN | CREB-binding protein (CBP) | CREB-binding protein (CREBBP) | CREBBP | ||
| Type: | Transcription Coactivator | ||
| Mol. Mass.: | 265411.66 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q92793 | ||
| Residue: | 2442 | ||
| Sequence: |
| ||
| BDBM274323 | |||
| n/a | |||
| Name | BDBM274323 | ||
| Synonyms: | Ethyl 6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2-(2-methoxypyridin-3-yl)-3-methyl-4-oxo-5,6-dihydropyrrolo[3,4-b]pyrrole-1(4H)-carboxylate | US9550796, Example 124 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H27ClN6O4 | ||
| Mol. Mass. | 571.026 | ||
| SMILES | CCOC(=O)n1c2C(N(C(=O)c2c(C)c1-c1cccnc1OC)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1 |(.92,-4.8,;2.01,-3.71,;1.61,-2.22,;2.7,-1.14,;4.18,-1.53,;2.3,.35,;.83,.83,;-.63,.35,;-1.54,1.6,;-.63,2.84,;-1.4,4.18,;.83,2.37,;2.3,2.84,;3.07,4.18,;3.2,1.6,;4.74,1.6,;5.51,.26,;7.05,.26,;7.82,1.6,;7.05,2.93,;5.51,2.93,;4.74,4.26,;5.51,5.6,;-3.08,1.6,;-3.85,2.93,;-5.39,2.93,;-6.16,4.26,;-6.16,1.6,;-7.66,1.28,;-7.82,-.25,;-6.42,-.88,;-6.02,-2.37,;-5.39,.26,;-3.85,.26,;-1.03,-1.14,;.06,-2.22,;-.34,-3.71,;-1.83,-4.11,;-2.23,-5.6,;-2.92,-3.02,;-2.52,-1.53,)| | ||
| Structure | 
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