| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50001853 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_146420 |
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| IC50 | 6.9±n/a nM |
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| Citation |  Chandrakumar, NS; Yonan, PK; Stapelfeld, A; Savage, M; Rorbacher, E; Contreras, PC; Hammond, D Preparation and opioid activity of analogues of the analgesic dipeptide 2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide. J Med Chem35:223-33 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44503.11 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
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| Residue: | 398 |
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| Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50001853 |
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| n/a |
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| Name | BDBM50001853 |
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| Synonyms: | 2-Amino-N-(2-fluoro-1-methyl-6-phenyl-hex-2-enyl)-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionamide | CHEMBL76062 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31FN2O2 |
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| Mol. Mass. | 398.5135 |
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| SMILES | CC(NC(=O)C(N)Cc1c(C)cc(O)cc1C)C(\F)=C\CCCc1ccccc1 |
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| Structure | 
|
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