Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50003745 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_201725 |
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Ki | 3.6±n/a nM |
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Citation | de Costa, BR; Dominguez, C; He, XS; Williams, W; Radesca, L; Bowen, W Synthesis and biological evaluation of conformationally restricted 2-(1-pyrrolidinyl)-N-[2-(3,4-dichlorophenyl)ethyl]-N-methylethylenediam ines as sigma receptor ligands. 1. Pyrrolidine, piperidine, homopiperidine, and tetrahydroisoquinoline classes. J Med Chem35:4334-43 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50003745 |
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n/a |
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Name | BDBM50003745 |
Synonyms: | 1-[2-(3,4-Dichloro-phenyl)-ethyl]-3-pyrrolidin-1-yl-piperidine | CHEMBL137794 |
Type | Small organic molecule |
Emp. Form. | C17H24Cl2N2 |
Mol. Mass. | 327.292 |
SMILES | Clc1ccc(CCN2CCCC(C2)N2CCCC2)cc1Cl |
Structure |
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