| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
|---|
| Ligand | BDBM50004556 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_45061 (CHEMBL658057) |
|---|
| Ki | 3.4±n/a nM |
|---|
| Citation |  Hartman, GD; Halczenko, W; Prugh, JD; Smith, RL; Sugrue, MF; Mallorga, P; Michelson, SR; Randall, WC; Schwam, H; Sondey, JM Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors. J Med Chem35:3027-33 (1992) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbonic anhydrase 2 |
|---|
| Name: | Carbonic anhydrase 2 |
|---|
| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 29250.71 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00918 |
|---|
| Residue: | 260 |
|---|
| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
|
|
|
|---|
| BDBM50004556 |
|---|
| n/a |
|---|
| Name | BDBM50004556 |
|---|
| Synonyms: | 5-[(2-Fluoro-ethylamino)-methyl]-thieno[2,3-b]furan-2-sulfonic acid amide | CHEMBL101370 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H11FN2O3S2 |
|---|
| Mol. Mass. | 278.324 |
|---|
| SMILES | NS(=O)(=O)c1cc2cc(CNCCF)sc2o1 |
|---|
| Structure | 
|
|---|
Search and Browse
