| Reaction Details |
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 | Report a problem with these data |
| Target | 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) |
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| Ligand | BDBM50247345 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1677511 (CHEMBL4027654) |
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| IC50 | 143±n/a nM |
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| Citation |  Li, B; Ni, S; Mao, F; Chen, F; Liu, Y; Wei, H; Chen, W; Zhu, J; Lan, L; Li, J Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity. J Med Chem61:224-250 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) |
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| Name: | 4,4'-diapophytoene desaturase (4,4'-diaponeurosporene-forming) |
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| Synonyms: | 4,4'-diapophytoene desaturase | CRTN_STAAE | Dehydrosqualene desaturase | Diapophytoene desaturase | crtN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56731.85 |
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| Organism: | Staphylococcus aureus (strain Newman) |
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| Description: | ChEMBL_116799 |
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| Residue: | 502 |
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| Sequence: | MKIAVIGAGVTGLAAAARIASQGHEVTIFEKNNNVGGRMNQLKKDGFTFDMGPTIVMMPD
VYKDVFTACGKNYEDYIELRQLRYIYDVYFDHDDRITVPTDLAELQQMLESIEPGSTHGF
MSFLTDVYKKYEIARRYFLERTYRKPSDFYNMTSLVQGAKLKTLNHADQLIEHYIDNEKI
QKLLAFQTLYIGIDPKRGPSLYSIIPMIEMMFGVHFIKGGMYGMAQGLAQLNKDLGVNIE
LNAEIEQIIIDPKFKRADAIKVNGDIRKFDKILCTADFPSVAESLMPDFAPIKKYPPHKI
ADLDYSCSAFLMYIGIDIDVTDQVRLHNVIFSDDFRGNIEEIFEGRLSYDPSIYVYVPAV
ADKSLAPEGKTGIYVLMPTPELKTGSGIDWSDEALTQQIKEIIYRKLATIEVFEDIKSHI
VSETIFTPNDFEQTYHAKFGSAFGLMPTLAQSNYYRPQNVSRDYKDLYFAGASTHPGAGV
PIVLTSAKITVDEMIKDIERGV
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| BDBM50247345 |
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| n/a |
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| Name | BDBM50247345 |
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| Synonyms: | CHEMBL4074126 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20Cl2N2 |
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| Mol. Mass. | 347.282 |
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| SMILES | Cl.CN(C\C=C\c1ccc(Cl)cc1)Cc1cccc2cc[nH]c12 |
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| Structure | 
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