Reaction Details |
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Target | Ubiquitin carboxyl-terminal hydrolase 7 |
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Ligand | BDBM50250951 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1682839 (CHEMBL4033116) |
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EC50 | 36500±n/a nM |
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Citation | Di Lello, P; Pastor, R; Murray, JM; Blake, RA; Cohen, F; Crawford, TD; Drobnick, J; Drummond, J; Kategaya, L; Kleinheinz, T; Maurer, T; Rougé, L; Zhao, X; Wertz, I; Ndubaku, C; Tsui, V Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques. J Med Chem60:10056-10070 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin carboxyl-terminal hydrolase 7 |
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Name: | Ubiquitin carboxyl-terminal hydrolase 7 |
Synonyms: | Deubiquitinating enzyme 7 | HAUSP | Herpesvirus-associated ubiquitin-specific protease | UBP7_HUMAN | USP7 | Ubiquitin thioesterase 7 | Ubiquitin-specific-processing protease 7 |
Type: | PROTEIN |
Mol. Mass.: | 128274.45 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1469483 |
Residue: | 1102 |
Sequence: | MNHQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVALSDGHNTAEEDME
DDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQ
CNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPE
KGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRK
AVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELC
RVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNI
FESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIK
INDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKF
DDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQL
VERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNS
SLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTI
FLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVM
CDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSEL
PTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFF
KSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLN
SQFREEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQEDELLE
CLSPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLLRIHQGEHFREV
MKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLD
HFNKAPKRSRYTYLEKAIKIHN
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BDBM50250951 |
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n/a |
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Name | BDBM50250951 |
Synonyms: | CHEMBL4063215 |
Type | Small organic molecule |
Emp. Form. | C17H15N3O2 |
Mol. Mass. | 293.3199 |
SMILES | Nc1nc(N)c(cc1-c1ccc(O)cc1)-c1ccc(O)cc1 |
Structure |
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