| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear factor of activated T-cells, cytoplasmic 1 |
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| Ligand | BDBM50251451 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1683764 |
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| EC50 | 7580±n/a nM |
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| Citation |  Shaw, SJ; Goff, DA; Lin, N; Singh, R; Li, W; McLaughlin, J; Baltgalvis, KA; Payan, DG; Kinsella, TM Developing DYRK inhibitors derived from the meridianins as a means of increasing levels of NFAT in the nucleus. Bioorg Med Chem Lett27:2617-2621 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear factor of activated T-cells, cytoplasmic 1 |
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| Name: | Nuclear factor of activated T-cells, cytoplasmic 1 |
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| Synonyms: | NF-ATc | NF-ATc1 | NFAC1_HUMAN | NFAT transcription complex cytosolic component | NFAT2 | NFATC | NFATC1 | Nuclear factor of activated T-cells cytoplasmic 1 | Nuclear factor of activated T-cells, cytoplasmic 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 101251.15 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_11335 |
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| Residue: | 943 |
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| Sequence: | MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASSNVSPALPLPT
AHSTLPAPCHNLQTSTPGIIPPADHPSGYGAALDGGPAGYFLSSGHTRPDGAPALESPRI
EITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSR
SCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPST
SPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSW
LGNTTQYTSSAIVAAINALTTDSSLDLGDGVPVKSRKTTLEQPPSVALKVEPVGEDLGSP
PPPADFAPEDYSSFQHIRKGGFCDQYLAVPQHPYQWAKPKPLSPTSYMSPTLPALDWQLP
SHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQLHGYLENEPLMLQLFIGT
ADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENSMRAVIDCAGILKLR
NSDIELRKGETDIGRKNTRVRLVFRVHVPQPSGRTLSLQVASNPIECSQRSAQELPLVEK
QSTDSYPVVGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVVEI
PPFRNQRITSPVHVSFYVCNGKRKRSQYQRFTYLPANVPIIKTEPTDDYEPAPTCGPVSQ
GLSPLPRPYYSQQLAMPPDPSSCLVAGFPPCPQRSTLMPAAPGVSPKLHDLSPAAYTKGV
ASPGHCHLGLPQPAGEAPAVQDVPRPVATHPGSPGQPPPALLPQQVSAPPSSSCPPGLEH
SLCPSSPSPPLPPATQEPTCLQPCSPACPPATGRPQHLPSTVRRDESPTAGPRLLPEVHE
DGSPNLAPIPVTVKREPEELDQLYLDDVNEIIRNDLSSTSTHS
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| BDBM50251451 |
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| n/a |
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| Name | BDBM50251451 |
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| Synonyms: | CHEMBL4069163 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14FN3 |
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| Mol. Mass. | 303.333 |
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| SMILES | Fc1ccc(Cn2cc(-c3ccncc3)c3ccncc23)cc1 |
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| Structure | 
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