Reaction Details |
| Report a problem with these data |
Target | Polyunsaturated fatty acid 5-lipoxygenase |
---|
Ligand | BDBM50007055 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_3800 (CHEMBL619875) |
---|
IC50 | 600±n/a nM |
---|
Citation | Bird, na; Bruneau, P; Crawley, GC; Edwards, MP; Foster, SJ; Girodeau, JM; Kingston, JF; McMillan, RM (Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity. J Med Chem34:2176-86 (1991) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Polyunsaturated fatty acid 5-lipoxygenase |
---|
Name: | Polyunsaturated fatty acid 5-lipoxygenase |
Synonyms: | 5-LO | 5-Lipo-oxygenase (5-LOX) | 5-Lipoxygenase (5-LO) | 5-Lipoxygenase (LOX) | 5-Lipoygenase | 5-lipoxygenase/FLAP | ALOX5 | Arachidonate 5-lipoxygenase | LOG5 | LOX5_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 77972.74 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant protein was purified from E. coli lysate. After ammonium sulfate precipitation and subsequent steps, the supernatant (S100) was used for 5-LO activity assay.
|
Residue: | 674 |
Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDE
ELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLA
RDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL
NYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNG
CNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDP
CTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDF
HVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECG
LFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWE
AIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYL
TVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCW
HLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPY
YYLSPDRIPNSVAI
|
|
|
BDBM50007055 |
---|
n/a |
---|
Name | BDBM50007055 |
Synonyms: | 4-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]-propyl}-thiazole | CHEMBL20905 |
Type | Small organic molecule |
Emp. Form. | C24H23NO2S |
Mol. Mass. | 389.51 |
SMILES | CCC(OC)(c1cscn1)c1cccc(OCc2ccc3ccccc3c2)c1 |
Structure |
|