Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Metabotropic glutamate receptor 2 | ||
Ligand | BDBM50257550 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1689940 (CHEMBL4040510) | ||
Ki | 6±n/a nM | ||
Citation | Doornbos, MLJ; Cid, JM; Haubrich, J; Nunes, A; van de Sande, JW; Vermond, SC; Mulder-Krieger, T; Trabanco, AA; Ahnaou, A; Drinkenburg, WH; Lavreysen, H; Heitman, LH; IJzerman, AP; Tresadern, G Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2. J Med Chem60:6704-6720 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Metabotropic glutamate receptor 2 | |||
Name: | Metabotropic glutamate receptor 2 | ||
Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 | ||
Type: | Enzyme | ||
Mol. Mass.: | 95584.88 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14416 | ||
Residue: | 872 | ||
Sequence: |
| ||
BDBM50257550 | |||
n/a | |||
Name | BDBM50257550 | ||
Synonyms: | CHEMBL4075762 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H19Cl2F3N4O | ||
Mol. Mass. | 459.292 | ||
SMILES | O[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC(F)(F)F)nnc2c1Cl |r,wU:4.7,wD:1.0,(51.9,-27.77,;51.91,-26.23,;53.25,-25.46,;53.26,-23.92,;51.92,-23.16,;50.58,-23.92,;50.58,-25.45,;51.92,-21.62,;53.26,-20.85,;54.59,-21.62,;55.93,-20.85,;55.92,-19.3,;54.59,-18.53,;53.26,-19.3,;51.93,-18.53,;57.25,-18.52,;58.59,-19.29,;59.91,-18.52,;59.91,-16.98,;61.05,-15.94,;62.56,-16.26,;63.04,-17.72,;62.02,-18.87,;64.55,-18.03,;63.44,-19.2,;60.42,-14.54,;58.89,-14.71,;58.58,-16.21,;57.24,-16.99,;55.91,-16.22,)| | ||
Structure |