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TargetMetabotropic glutamate receptor 2
LigandBDBM50257550
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1689940 (CHEMBL4040510)
Ki 6±n/a nM
Citation Doornbos, MLJCid, JMHaubrich, JNunes, Avan de Sande, JWVermond, SCMulder-Krieger, TTrabanco, AAAhnaou, ADrinkenburg, WHLavreysen, HHeitman, LHIJzerman, APTresadern, G Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2. J Med Chem60:6704-6720 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Metabotropic glutamate receptor 2
Name:Metabotropic glutamate receptor 2
Synonyms:GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2
Type:Enzyme
Mol. Mass.:95584.88
Organism:Homo sapiens (Human)
Description:Q14416
Residue:872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ
RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI
CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY
FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK
VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL
ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR
DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL
DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC
GLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKA
SGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARI
FGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLR
CNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIF
YVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
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BDBM50257550
n/a
NameBDBM50257550
Synonyms:CHEMBL4075762
TypeSmall organic molecule
Emp. Form.C20H19Cl2F3N4O
Mol. Mass.459.292
SMILESO[C@H]1CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC(F)(F)F)nnc2c1Cl |r,wU:4.7,wD:1.0,(51.9,-27.77,;51.91,-26.23,;53.25,-25.46,;53.26,-23.92,;51.92,-23.16,;50.58,-23.92,;50.58,-25.45,;51.92,-21.62,;53.26,-20.85,;54.59,-21.62,;55.93,-20.85,;55.92,-19.3,;54.59,-18.53,;53.26,-19.3,;51.93,-18.53,;57.25,-18.52,;58.59,-19.29,;59.91,-18.52,;59.91,-16.98,;61.05,-15.94,;62.56,-16.26,;63.04,-17.72,;62.02,-18.87,;64.55,-18.03,;63.44,-19.2,;60.42,-14.54,;58.89,-14.71,;58.58,-16.21,;57.24,-16.99,;55.91,-16.22,)|
Structure
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