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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Metabotropic glutamate receptor 2 | ||
| Ligand | BDBM50257567 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1689940 (CHEMBL4040510) | ||
| Ki | 11±n/a nM | ||
| Citation |  Doornbos, MLJ; Cid, JM; Haubrich, J; Nunes, A; van de Sande, JW; Vermond, SC; Mulder-Krieger, T; Trabanco, AA; Ahnaou, A; Drinkenburg, WH; Lavreysen, H; Heitman, LH; IJzerman, AP; Tresadern, G Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2. J Med Chem60:6704-6720 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Metabotropic glutamate receptor 2 | |||
| Name: | Metabotropic glutamate receptor 2 | ||
| Synonyms: | GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 95584.88 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14416 | ||
| Residue: | 872 | ||
| Sequence: |
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| BDBM50257567 | |||
| n/a | |||
| Name | BDBM50257567 | ||
| Synonyms: | CHEMBL4081244 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H18Cl2F3N3O2 | ||
| Mol. Mass. | 460.277 | ||
| SMILES | O[C@H]1CC[C@@H](CC1)Oc1ccc(cc1Cl)-c1ccn2c(CC(F)(F)F)nnc2c1Cl |r,wU:4.7,wD:1.0,(6.62,-15.31,;6.63,-13.77,;7.96,-13,;7.97,-11.46,;6.64,-10.7,;5.3,-11.46,;5.3,-12.99,;6.64,-9.16,;7.98,-8.39,;9.31,-9.16,;10.65,-8.39,;10.64,-6.84,;9.31,-6.07,;7.98,-6.84,;6.64,-6.07,;11.97,-6.06,;13.3,-6.83,;14.63,-6.06,;14.63,-4.52,;15.77,-3.48,;17.28,-3.8,;17.76,-5.26,;16.73,-6.41,;19.27,-5.57,;18.15,-6.74,;15.14,-2.08,;13.61,-2.25,;13.3,-3.75,;11.96,-4.53,;10.62,-3.76,)| | ||
| Structure | 
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