| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
|---|
| Ligand | BDBM193117 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1690006 |
|---|
| IC50 | 4100±n/a nM |
|---|
| Citation |  Joncour, A; Desroy, N; Housseman, C; Bock, X; Bienvenu, N; Cherel, L; Labeguere, V; Peixoto, C; Annoot, D; Lepissier, L; Heiermann, J; Hengeveld, WJ; Pilzak, G; Monjardet, A; Wakselman, E; Roncoroni, V; Le Tallec, S; Galien, R; David, C; Vandervoort, N; Christophe, T; Conrath, K; Jans, M; Wohlkonig, A; Soror, S; Steyaert, J; Touitou, R; Fleury, D; Vercheval, L; Mollat, P; Triballeau, N; van der Aar, E; Brys, R; Heckmann, B Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors. J Med Chem60:7371-7392 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
|---|
| Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
|---|
| Synonyms: | 3.1.4.39 | Atx | Autotaxin | E-NPP 2 | ENPP2_RAT | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Enpp2 | Extracellular lysophospholipase D | LysoPLD | Npps2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 101590.86 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_116829 |
|---|
| Residue: | 887 |
|---|
| Sequence: | MARQGCLGSFQVISLFTFAISVNICLGFTASRIKRAEWDEGPPTVLSDSPWTNTSGSCKG
RCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCS
EDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKK
GSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDAS
FHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERP
SVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHG
MEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSINNSKYDPKTIIANLTCKKPDQHF
KPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDVYKKPSGKCFFQGDHGFDNKV
NSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFR
PTMPDEVSRPNYPGIMYLQSEFDLGCTCDDKVEPKNKLEELNKRLHTKGSTEAETGKFRG
SKHENKKNLNGSVEPRKERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTI
SKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDA
FLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQY
VEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWV
EELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI
|
|
|
|---|
| BDBM193117 |
|---|
| n/a |
|---|
| Name | BDBM193117 |
|---|
| Synonyms: | US10526329, Compound 192 | US11072611, Compound 192 | US9670204, 192 N-(6-(4-((1H-imidazol-5-yl)methyl)piperazin-1-yl)-2-ethylimidazo[1,2-a]pyridin-3-yl)-4-(4-fluorophenyl)-N-methylthiazol-2-amine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H29FN8S |
|---|
| Mol. Mass. | 516.636 |
|---|
| SMILES | CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCN(Cc2cnc[nH]2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
