Reaction Details |
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Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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Ligand | BDBM192923 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1690005 (CHEMBL4040575) |
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IC50 | 1410±n/a nM |
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Citation | Joncour, A; Desroy, N; Housseman, C; Bock, X; Bienvenu, N; Cherel, L; Labeguere, V; Peixoto, C; Annoot, D; Lepissier, L; Heiermann, J; Hengeveld, WJ; Pilzak, G; Monjardet, A; Wakselman, E; Roncoroni, V; Le Tallec, S; Galien, R; David, C; Vandervoort, N; Christophe, T; Conrath, K; Jans, M; Wohlkonig, A; Soror, S; Steyaert, J; Touitou, R; Fleury, D; Vercheval, L; Mollat, P; Triballeau, N; van der Aar, E; Brys, R; Heckmann, B Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors. J Med Chem60:7371-7392 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
Synonyms: | ATX | Autotaxin | Autotaxin (ATX) | E-NPP 2 | ENPP2 | ENPP2_HUMAN | Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP2) | Extracellular lysophospholipase D | LysoPLD | PDNP2 |
Type: | Enzyme |
Mol. Mass.: | 99007.13 |
Organism: | Homo sapiens (Human) |
Description: | Q13822 |
Residue: | 863 |
Sequence: | MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCK
GRCFELQEAGPPDCRCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKAAECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
TFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRSKFSNNAKYDPKAIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYG
RPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVS
PSFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVL
VKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYVEGSSIPVPTHYYSIITSCLDFTQ
PADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIEHLTSLDFFR
KTSRSYPEILTLKTYLHTYESEI
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BDBM192923 |
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n/a |
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Name | BDBM192923 |
Synonyms: | US10526329, Compound 138 | US11072611, Compound 137 | US9670204, 137 2-((2-ethyl-6-(1-(methylsulfonyl)piperidin-4-yl)imidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carboxamide |
Type | Small organic molecule |
Emp. Form. | C26H29FN6O3S2 |
Mol. Mass. | 556.675 |
SMILES | CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C(N)=O)-c1ccc(F)cc1)C1CCN(CC1)S(C)(=O)=O |
Structure |
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