| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysosomal alpha-glucosidase |
|---|
| Ligand | BDBM50259130 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1691145 |
|---|
| IC50 | 27710±n/a nM |
|---|
| Citation |  Wang, G; Peng, Z; Wang, J; Li, X; Li, J Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential?-glucosidase inhibitors. Eur J Med Chem125:423-429 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysosomal alpha-glucosidase |
|---|
| Name: | Lysosomal alpha-glucosidase |
|---|
| Synonyms: | 70 kDa lysosomal alpha-glucosidase | 76 kDa lysosomal alpha-glucosidase | Acid maltase | Aglucosidase alfa | Alpha glucosidase | GAA | LYAG_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 105312.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1506060 |
|---|
| Residue: | 952 |
|---|
| Sequence: | MGVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLEETHPAHQQGA
SRPGPRDAQAHPGRPRAVPTQCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGLQGA
QMGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLH
FTIKDPANRRYEVPLETPHVHSRAPSPLYSVEFSEEPFGVIVRRQLDGRVLLNTTVAPLF
FADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLA
LEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGY
PFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDG
FRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKV
WPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELEN
PPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISR
STFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVR
WTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAG
ETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPV
EALGSLPPPPAAPREPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQP
MALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQ
LQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC
|
|
|
|---|
| BDBM50259130 |
|---|
| n/a |
|---|
| Name | BDBM50259130 |
|---|
| Synonyms: | CHEMBL4082380 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H21N7OS |
|---|
| Mol. Mass. | 479.556 |
|---|
| SMILES | O=C(Cn1cc(CSc2nnc(-c3ccccc3)c(n2)-c2ccccc2)nn1)Nc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
