Reaction Details | |||
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Target | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | ||
Ligand | BDBM50259764 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_1691739 | ||
IC50 | 78±n/a nM | ||
Citation | Wei, M; Zhang, X; Wang, X; Song, Z; Ding, J; Meng, LH; Zhang, A SAR study of 5-alkynyl substituted quinazolin-4(3H)-ones as phosphoinositide 3-kinase delta (PI3K?) inhibitors. Eur J Med Chem125:1156-1171 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | |||
Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | ||
Synonyms: | PI3-kinase p110 subunit delta | PI3-kinase p110-delta subunit | PI3-kinase subunit p110-delta | PI3K | PIK3CD | PK3CD_HUMAN | Phosphatidylinositol 4,5-biphosphate 3-kinase catalytic subunit delta (PIK3CD) | Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta | Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta (PI3K delta) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic (PI3K) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta (PI3Kdelta) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform ( PI3K-delta) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3K delta) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3K) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3K-delta) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3Kd) | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3Kdelta) | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 119489.41 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O00329 | ||
Residue: | 1044 | ||
Sequence: |
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BDBM50259764 | |||
n/a | |||
Name | BDBM50259764 | ||
Synonyms: | CHEMBL4105575 | ||
Type | Small organic molecule | ||
Emp. Form. | C35H35FN8O | ||
Mol. Mass. | 602.7038 | ||
SMILES | Nc1ncnc(N2CCC[C@H]2c2nc3cccc(C#CCN4CCC(CC4)C4CC(F)C4)c3c(=O)n2-c2ccccc2)c1C#N |r,wD:10.11,(17.77,-40.78,;17.47,-39.27,;16.01,-38.78,;15.71,-37.27,;16.86,-36.25,;18.32,-36.74,;19.48,-35.73,;20.98,-36.06,;21.77,-34.74,;20.75,-33.58,;19.34,-34.19,;18.01,-33.4,;16.66,-34.16,;15.34,-33.37,;14,-34.13,;12.68,-33.35,;12.69,-31.81,;14.04,-31.05,;14.05,-29.51,;14.07,-27.97,;14.09,-26.43,;15.43,-25.68,;16.74,-26.47,;18.08,-25.72,;18.11,-24.18,;16.79,-23.39,;15.43,-24.14,;19.46,-23.42,;20.94,-23.84,;21.35,-22.36,;22.7,-21.61,;19.88,-21.94,;15.36,-31.83,;16.7,-31.08,;16.72,-29.54,;18.02,-31.86,;19.37,-31.11,;20.7,-31.9,;22.04,-31.14,;22.06,-29.6,;20.73,-28.82,;19.38,-29.57,;18.63,-38.25,;20.08,-38.75,;21.54,-39.24,)| | ||
Structure |