| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
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| Ligand | BDBM50260867 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1694696 |
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| IC50 | 251±n/a nM |
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| Citation |  Miah, AH; Champigny, AC; Graves, RH; Hodgson, ST; Percy, JM; Procopiou, PA Identification of pyrazolopyrimidine arylsulfonamides as CC-chemokine receptor 4 (CCR4) antagonists. Bioorg Med Chem25:5327-5340 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 4 |
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| Name: | C-C chemokine receptor type 4 |
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| Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41406.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51679 |
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| Residue: | 360 |
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| Sequence: | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
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| BDBM50260867 |
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| n/a |
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| Name | BDBM50260867 |
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| Synonyms: | CHEMBL4080352 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13Cl2N5O4S |
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| Mol. Mass. | 430.266 |
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| SMILES | COc1nn(C2COC2)c2ncnc(NS(=O)(=O)c3cccc(Cl)c3Cl)c12 |
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| Structure | 
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