| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
|---|
| Ligand | BDBM50261040 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1695422 |
|---|
| IC50 | 3000±n/a nM |
|---|
| Citation |  Paudel, S; Min, X; Acharya, S; Khadka, DB; Yoon, G; Kim, KM; Cheon, SH Triple reuptake inhibitors: Design, synthesis and structure-activity relationship of benzylpiperidine-tetrazoles. Bioorg Med Chem25:5278-5289 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent noradrenaline transporter |
|---|
| Name: | Sodium-dependent noradrenaline transporter |
|---|
| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 69337.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23975 |
|---|
| Residue: | 617 |
|---|
| Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
|
|
|
|---|
| BDBM50261040 |
|---|
| n/a |
|---|
| Name | BDBM50261040 |
|---|
| Synonyms: | CHEMBL4099475 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H29N5O |
|---|
| Mol. Mass. | 403.52 |
|---|
| SMILES | CC(=O)c1cccc(c1)-c1nnnn1CCCN1CCC(Cc2ccccc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
