| Reaction Details |
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 | Report a problem with these data |
| Target | D(1A)/D(2) dopamine receptor |
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| Ligand | BDBM50010699 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_59611 (CHEMBL670947) |
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| Ki | 511±n/a nM |
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| Citation |  Gao, YG; Baldessarini, RJ; Kula, NS; Neumeyer, JL Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues. J Med Chem33:1800-5 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| D(1A)/D(2) dopamine receptor |
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| Name: | D(1A)/D(2) dopamine receptor |
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| Synonyms: | Dopamine receptor |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 59578 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | D(2) dopamine receptor |
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| Synonyms: | DOPAMINE D2 | DRD2 | DRD2_BOVIN | Dopamine D2 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50698.79 |
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| Organism: | BOVINE |
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| Description: | P20288 |
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| Residue: | 444 |
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| Sequence: | MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMS
RRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNS
AVNPIIYTTFNIEFRKAFLKILHC
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| Component 2 |
| Name: | D(1A) dopamine receptor |
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| Synonyms: | D(1A) dopamine receptor | D1AR | DOPAMINE D1 | DRD1 | DRD1_BOVIN | Dopamine receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49330.65 |
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| Organism: | BOVINE |
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| Description: | DOPAMINE D1 DRD1 BOVINE::Q95136 |
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| Residue: | 446 |
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| Sequence: | MRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLG
KTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKN
CQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGS
GETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIET
VSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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| BDBM50010699 |
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| n/a |
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| Name | BDBM50010699 |
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| Synonyms: | (+)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,10,11-triol | 6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,10,11-triol | CHEMBL54183 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17NO3 |
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| Mol. Mass. | 283.3218 |
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| SMILES | CN1CCc2cc(O)cc-3c2[C@@H]1Cc1ccc(O)c(O)c-31 |
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| Structure | 
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