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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cholinesterase | ||
| Ligand | BDBM50262656 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1697027 (CHEMBL4047917) | ||
| IC50 | 2740±n/a nM | ||
| Citation |  Makhaeva, GF; Lushchekina, SV; Boltneva, NP; Serebryakova, OG; Rudakova, EV; Ustyugov, AA; Bachurin, SO; Shchepochkin, AV; Chupakhin, ON; Charushin, VN; Richardson, RJ 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment. Bioorg Med Chem25:5981-5994 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cholinesterase | |||
| Name: | Cholinesterase | ||
| Synonyms: | BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 65643.35 | ||
| Organism: | Equus caballus (Horse) | ||
| Description: | P81908 | ||
| Residue: | 574 | ||
| Sequence: |
| ||
| BDBM50262656 | |||
| n/a | |||
| Name | BDBM50262656 | ||
| Synonyms: | CHEMBL4067342 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H32BF4NO | ||
| Mol. Mass. | 485.364 | ||
| SMILES | F[B-](F)(F)F.C[n+]1c2ccccc2c(-c2cc(cc(c2O)C(C)(C)C)C(C)(C)C)c2ccccc12 |(13.27,-31.17,;11.94,-31.94,;10.61,-31.17,;11.94,-33.48,;11.93,-30.4,;12.82,-30.29,;12.82,-28.75,;11.49,-27.98,;10.16,-28.75,;8.82,-27.98,;8.83,-26.44,;10.15,-25.67,;11.49,-26.43,;12.82,-25.65,;12.82,-24.11,;11.49,-23.36,;11.49,-21.82,;12.83,-21.04,;14.16,-21.81,;14.16,-23.35,;15.49,-24.13,;15.49,-21.04,;16.83,-21.82,;15.5,-19.5,;16.82,-20.26,;10.15,-21.06,;10.15,-19.52,;8.82,-21.83,;8.81,-20.28,;14.16,-26.43,;15.49,-25.67,;16.82,-26.43,;16.82,-27.97,;15.49,-28.74,;14.16,-27.97,)| | ||
| Structure | 
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