Reaction Details |
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Target | Melatonin receptor type 1A |
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Ligand | BDBM50263729 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1698235 (CHEMBL4049125) |
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Ki | 2.40±n/a nM |
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Citation | Rivara, S; Scalvini, L; Lodola, A; Mor, M; Caignard, DH; Delagrange, P; Collina, S; Lucini, V; Scaglione, F; Furiassi, L; Mari, M; Lucarini, S; Bedini, A; Spadoni, G Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands. J Med Chem61:3726-3737 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melatonin receptor type 1A |
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Name: | Melatonin receptor type 1A |
Synonyms: | MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A |
Type: | Enzyme |
Mol. Mass.: | 39392.94 |
Organism: | Homo sapiens (Human) |
Description: | P48039 |
Residue: | 350 |
Sequence: | MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
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BDBM50263729 |
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n/a |
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Name | BDBM50263729 |
Synonyms: | CHEMBL4074273 |
Type | Small organic molecule |
Emp. Form. | C18H20N2O |
Mol. Mass. | 280.3642 |
SMILES | CC(=O)NCC1CN(c2ccccc2)c2ccccc2C1 |
Structure |
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