Ki Summary

Reaction Details

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Target

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Ligand

BDBM50264241

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1698408 (CHEMBL4049298)

IC50

>5000±n/a nM

Citation

Nikolaou, A; Ninou, I; Kokotou, MG; Kaffe, E; Afantitis, A; Aidinis, V; Kokotos, G Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model. J Med Chem61:3697-3711 (2018) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Name:

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

Synonyms:

Type:

PROTEIN

Mol. Mass.:

98896.47

Organism:

Mus musculus

Description:

n/a

Residue:

862

Sequence:

MARQGCFGSYQVISLFTFAIGVNLCLGFTASRIKRAEWDEGPPTVLSDSPWTNTSGSCKG
RCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCS
EDCLSRGDCCTNYQVVCKGESHWVDDDCEEIRVPECPAGFVRPPLIIFSVDGFRASYMKK
GSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDAT
FHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERP
SVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHG
MEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRPKIPNNLKYDPKAIIANLTCKKPDQHF
KPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKV
NSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFR
PTLPEEVSRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLEELNKRLHTKGSTEERHLLYGR
PAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSP
GFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWTYFQRVLV
KKYASERNGVNVISGPIFDYNYNGLRDIEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQP
ADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRK
TSRSYSEILTLKTYLHTYESEI

BDBM50264241

n/a

Name

BDBM50264241

Synonyms:

CHEMBL4065969

Type

Small organic molecule

Emp. Form.

C18H25N3O6

Mol. Mass.

379.4076

SMILES

COC(=O)[C@H](CCC(=O)NO)NC(=O)CCCCNC(=O)c1ccccc1 |r|

Structure