| Reaction Details |
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 | Report a problem with these data |
| Target | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Ligand | BDBM347379 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1700506 (CHEMBL4051488) |
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| IC50 | 1.5±n/a nM |
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| Citation |  Antczak, MI; Zhang, Y; Wang, C; Doran, J; Naidoo, J; Voruganti, S; Williams, NS; Markowitz, SD; Ready, JM Inhibitors of 15-Prostaglandin Dehydrogenase To Potentiate Tissue Repair. J Med Chem60:3979-4001 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Name: | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] |
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| Synonyms: | 15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 28974.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15428 |
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| Residue: | 266 |
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| Sequence: | MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
AIMKITTSKGIHFQDYDTTPFQAKTQ
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| BDBM347379 |
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| n/a |
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| Name | BDBM347379 |
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| Synonyms: | US10869871, ID # SW211668-(33291-R | US20230285402, ID # SW211668-(33291-R-isomer) | US9789116, SW211668 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20N2OS3 |
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| Mol. Mass. | 412.591 |
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| SMILES | CCCC[S@@+]([O-])c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1 |r| |
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| Structure | 
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