Reaction Details |
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Target | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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Ligand | BDBM192946 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1700909 (CHEMBL4051891) |
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IC50 | 22±n/a nM |
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Citation | Desroy, N; Housseman, C; Bock, X; Joncour, A; Bienvenu, N; Cherel, L; Labeguere, V; Rondet, E; Peixoto, C; Grassot, JM; Picolet, O; Annoot, D; Triballeau, N; Monjardet, A; Wakselman, E; Roncoroni, V; Le Tallec, S; Blanque, R; Cottereaux, C; Vandervoort, N; Christophe, T; Mollat, P; Lamers, M; Auberval, M; Hrvacic, B; Ralic, J; Oste, L; van der Aar, E; Brys, R; Heckmann, B Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fib J Med Chem60:3580-3590 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
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Name: | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
Synonyms: | 3.1.4.39 | Atx | Autotaxin | E-NPP 2 | ENPP2_RAT | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Enpp2 | Extracellular lysophospholipase D | LysoPLD | Npps2 |
Type: | PROTEIN |
Mol. Mass.: | 101590.86 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_116829 |
Residue: | 887 |
Sequence: | MARQGCLGSFQVISLFTFAISVNICLGFTASRIKRAEWDEGPPTVLSDSPWTNTSGSCKG
RCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCS
EDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKK
GSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDAS
FHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERP
SVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHG
MEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSINNSKYDPKTIIANLTCKKPDQHF
KPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDVYKKPSGKCFFQGDHGFDNKV
NSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFR
PTMPDEVSRPNYPGIMYLQSEFDLGCTCDDKVEPKNKLEELNKRLHTKGSTEAETGKFRG
SKHENKKNLNGSVEPRKERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTI
SKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDA
FLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQY
VEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWV
EELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI
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BDBM192946 |
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n/a |
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Name | BDBM192946 |
Synonyms: | US11072611, Compound 141 | US9670204, 141 2-((2-ethyl-6-(1-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperidin-4-yl)imidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile |
Type | Small organic molecule |
Emp. Form. | C30H32FN7O2S |
Mol. Mass. | 573.684 |
SMILES | CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)C1CCN(CC(=O)N2CC(O)C2)CC1 |
Structure |
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