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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Aromatase | ||
| Ligand | BDBM50011761 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_50536 (CHEMBL661153) | ||
| IC50 | 111±n/a nM | ||
| Citation |  Stanek, J; Alder, A; Bellus, D; Bhatnagar, AS; Häusler, A; Schieweck, K Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones. J Med Chem34:1329-34 (1991) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Aromatase | |||
| Name: | Aromatase | ||
| Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 57888.92 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11511 | ||
| Residue: | 503 | ||
| Sequence: |
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| BDBM50011761 | |||
| n/a | |||
| Name | BDBM50011761 | ||
| Synonyms: | 1-(4-Amino-phenyl)-3-propyl-3-aza-bicyclo[3.1.1]heptane-2,4-dione | CHEMBL27698 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C15H18N2O2 | ||
| Mol. Mass. | 258.3156 | ||
| SMILES | CCCN1C(=O)C2CC(C2)(C1=O)c1ccc(N)cc1 |(.22,-8.94,;.22,-7.4,;1.55,-6.63,;1.55,-5.09,;.23,-4.32,;-1.11,-5.09,;.23,-2.78,;1.55,-2.01,;2.88,-2.78,;1.56,-3.55,;2.88,-4.32,;4.21,-5.09,;4.21,-2.01,;5.54,-2.8,;6.88,-2.04,;6.89,-.5,;8.22,.27,;5.54,.28,;4.2,-.47,)| | ||
| Structure | 
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