Reaction Details |
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Target | Aromatase |
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Ligand | BDBM50011762 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_84457 (CHEMBL692480) |
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IC50 | 230±n/a nM |
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Citation | Stanek, J; Alder, A; Bellus, D; Bhatnagar, AS; Häusler, A; Schieweck, K Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones. J Med Chem34:1329-34 (1991) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Aromatase |
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Name: | Aromatase |
Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM |
Type: | Enzyme |
Mol. Mass.: | 57888.92 |
Organism: | Homo sapiens (Human) |
Description: | P11511 |
Residue: | 503 |
Sequence: | MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
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BDBM50011762 |
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n/a |
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Name | BDBM50011762 |
Synonyms: | (1R,5S)1-(4-Amino-phenyl)-3-cyclohexylmethyl-3-aza-bicyclo[3.1.0]hexane-2,4-dione | (1S,5R)1-(4-Amino-phenyl)-3-cyclohexylmethyl-3-aza-bicyclo[3.1.0]hexane-2,4-dione | 1-(4-Amino-phenyl)-3-cyclohexylmethyl-3-aza-bicyclo[3.1.0]hexane-2,4-dione | CHEMBL281947 |
Type | Small organic molecule |
Emp. Form. | C18H22N2O2 |
Mol. Mass. | 298.3795 |
SMILES | Nc1ccc(cc1)C12CC1C(=O)N(CC1CCCCC1)C2=O |
Structure |
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