Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cytochrome P450 11B2, mitochondrial | ||
| Ligand | BDBM50011756 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_192302 (CHEMBL794467) | ||
| IC50 | 140000±n/a nM | ||
| Citation |  Stanek, J; Alder, A; Bellus, D; Bhatnagar, AS; Häusler, A; Schieweck, K Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0]hexane- and -[3.1.1]heptane-2,4- diones. J Med Chem34:1329-34 (1991) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cytochrome P450 11B2, mitochondrial | |||
| Name: | Cytochrome P450 11B2, mitochondrial | ||
| Synonyms: | Aldosterone synthase | C11B2_RAT | CYPXIB2 | Cyp11b-2 | Cyp11b2 | Cytochrome P450 11B | Cytochrome P450 11B2 | Cytochrome P450 11B2, mitochondrial | P450-Aldo-1 | Steroid 11-beta-hydroxylase | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 58260.64 | ||
| Organism: | Rattus norvegicus | ||
| Description: | ChEMBL_224979 | ||
| Residue: | 510 | ||
| Sequence: |
| ||
| BDBM50011756 | |||
| n/a | |||
| Name | BDBM50011756 | ||
| Synonyms: | 1-(4-Amino-phenyl)-3-cyclohexyl-3-aza-bicyclo[3.1.1]heptane-2,4-dione | CHEMBL27467 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H22N2O2 | ||
| Mol. Mass. | 298.3795 | ||
| SMILES | Nc1ccc(cc1)C12CC(C1)C(=O)N(C1CCCCC1)C2=O |(8.24,.27,;6.91,-.5,;6.9,-2.04,;5.55,-2.81,;4.22,-2.02,;4.21,-.47,;5.55,.28,;2.88,-2.79,;1.55,-2.02,;.23,-2.79,;1.57,-3.56,;.23,-4.33,;-1.11,-5.11,;1.55,-5.11,;1.55,-6.65,;2.88,-7.4,;2.88,-8.96,;1.55,-9.71,;.22,-8.94,;.22,-7.4,;2.88,-4.33,;4.22,-5.11,)| | ||
| Structure | 
| ||