| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM50268971 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1705580 (CHEMBL4056813) |
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| IC50 | 67±n/a nM |
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| Citation |  Bobileva, O; Ikaunieks, M; Duburs, G; Mandrika, I; Petrovska, R; Klovins, J; Loza, E Synthesis and evaluation of (E)-2-(5-phenylpent-2-en-4-ynamido)cyclohex-1-ene-1-carboxylate derivatives as HCA2 receptor agonists. Bioorg Med Chem25:4314-4329 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 41868.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
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| Residue: | 363 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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| BDBM50268971 |
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| n/a |
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| Name | BDBM50268971 |
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| Synonyms: | CHEMBL4072283 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18FNO3 |
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| Mol. Mass. | 315.3388 |
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| SMILES | OC(=O)C1=C(CCCC1)NC(=O)CCC#Cc1ccccc1F |t:3| |
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| Structure | 
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