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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M2 | ||
| Ligand | BDBM50270742 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1709496 (CHEMBL4119545) | ||
| Ki | 355±n/a nM | ||
| Citation |  Del Bello, F; Bonifazi, A; Giorgioni, G; Petrelli, R; Quaglia, W; Altomare, A; Falcicchio, A; Matucci, R; Vistoli, G; Piergentili, A Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments. Eur J Med Chem137:327-337 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M2 | |||
| Name: | Muscarinic acetylcholine receptor M2 | ||
| Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 | ||
| Type: | GPCR | ||
| Mol. Mass.: | 51730.61 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P08172 | ||
| Residue: | 466 | ||
| Sequence: |
| ||
| BDBM50270742 | |||
| n/a | |||
| Name | BDBM50270742 | ||
| Synonyms: | CHEMBL4129723 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H29NO3 | ||
| Mol. Mass. | 379.492 | ||
| SMILES | C(O[C@H]1CN2CCC1CC2)[C@@H]1COCC(O1)(c1ccccc1)c1ccccc1 |r,wU:10.11,wD:2.1,(44.01,-33.15,;45.34,-32.4,;46.67,-33.17,;46.66,-34.71,;47.99,-35.48,;49.32,-34.72,;49.33,-33.18,;48,-32.4,;47.27,-33.77,;48.55,-34.38,;42.68,-32.39,;42.67,-30.85,;41.35,-30.07,;40.02,-30.85,;39.99,-32.38,;41.35,-33.15,;38.66,-31.61,;38.66,-30.07,;37.33,-29.3,;35.99,-30.07,;36,-31.62,;37.33,-32.38,;39.22,-33.71,;37.68,-33.71,;36.91,-35.04,;37.69,-36.38,;39.24,-36.37,;40,-35.03,)| | ||
| Structure | 
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