Reaction Details |
| Report a problem with these data |
Target | Mitogen-activated protein kinase 8 |
---|
Ligand | BDBM50271776 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_1711683 |
---|
IC50 | 79±n/a nM |
---|
Citation | Price, DJ; Drewry, DH; Schaller, LT; Thompson, BD; Reid, PR; Maloney, PR; Liang, X; Banker, P; Buckholz, RG; Selley, PK; McDonald, OB; Smith, JL; Shearer, TW; Cox, RF; Williams, SP; Reid, RA; Tacconi, S; Faggioni, F; Piubelli, C; Sartori, I; Tessari, M; Wang, TY An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model. Bioorg Med Chem Lett28:1958-1963 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Mitogen-activated protein kinase 8 |
---|
Name: | Mitogen-activated protein kinase 8 |
Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) |
Type: | Enzyme |
Mol. Mass.: | 48297.57 |
Organism: | Homo sapiens (Human) |
Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). |
Residue: | 427 |
Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR
|
|
|
BDBM50271776 |
---|
n/a |
---|
Name | BDBM50271776 |
Synonyms: | CHEMBL4125907 |
Type | Small organic molecule |
Emp. Form. | C23H22N4O |
Mol. Mass. | 370.447 |
SMILES | CN(C)Cc1ccc(cc1)-c1cc2c(ccnc2[nH]1)-c1ccc(cc1)C(N)=O |
Structure |
|