| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Ligand | BDBM50271779 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1711679 (CHEMBL4121728) |
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| IC50 | 32±n/a nM |
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| Citation |  Price, DJ; Drewry, DH; Schaller, LT; Thompson, BD; Reid, PR; Maloney, PR; Liang, X; Banker, P; Buckholz, RG; Selley, PK; McDonald, OB; Smith, JL; Shearer, TW; Cox, RF; Williams, SP; Reid, RA; Tacconi, S; Faggioni, F; Piubelli, C; Sartori, I; Tessari, M; Wang, TY An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model. Bioorg Med Chem Lett28:1958-1963 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Name: | Calcium/calmodulin-dependent protein kinase kinase 2 |
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| Synonyms: | CAMKK2 | CAMKKB | Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKKB) | Calcium/calmodulin-dependent protein kinase kinase beta | KIAA0787 | KKCC2_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 64746.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_27437015 |
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| Residue: | 588 |
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| Sequence: | MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQP
PGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE
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| BDBM50271779 |
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| n/a |
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| Name | BDBM50271779 |
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| Synonyms: | CHEMBL4127479 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H28N4O3 |
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| Mol. Mass. | 456.5362 |
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| SMILES | Cc1ccc(OCCN2CCOCC2)cc1-c1cc2c(ccnc2[nH]1)-c1ccc(cc1)C(N)=O |
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| Structure | 
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