| Reaction Details |
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 | Report a problem with these data |
| Target | Histone lysine demethylase PHF8 |
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| Ligand | BDBM50273469 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1712927 (CHEMBL4122976) |
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| IC50 | 310000±n/a nM |
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| Citation |  Bhushan, B; Erdmann, A; Zhang, Y; Belle, R; Johannson, C; Oppermann, U; Hopkinson, RJ; Schofield, CJ; Kawamura, A Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases. Bioorg Med Chem26:2984-2991 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone lysine demethylase PHF8 |
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| Name: | Histone lysine demethylase PHF8 |
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| Synonyms: | Histone lysine demethylase PHF8 | Histone lysine demethylase PHF8 (PHF8) | KIAA1111 | Lysine-specific demethylase 7A/7B | PHD finger protein 8 | PHF8 | PHF8_HUMAN | ZNF422 |
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| Type: | Protein |
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| Mol. Mass.: | 117889.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UPP1 |
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| Residue: | 1060 |
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| Sequence: | MNRSRAIVQRGRVLPPPAPLDTTNLAGRRTLQGRAKMASVPVYCLCRLPYDVTRFMIECD
MCQDWFHGSCVGVEEEKAADIDLYHCPNCEVLHGPSIMKKRRGSSKGHDTHKGKPVKTGS
PTFVRELRSRTFDSSDEVILKPTGNQLTVEFLEENSFSVPILVLKKDGLGMTLPSPSFTV
RDVEHYVGSDKEIDVIDVTRQADCKMKLGDFVKYYYSGKREKVLNVISLEFSDTRLSNLV
ETPKIVRKLSWVENLWPEECVFERPNVQKYCLMSVRDSYTDFHIDFGGTSVWYHVLKGEK
IFYLIRPTNANLTLFECWSSSSNQNEMFFGDQVDKCYKCSVKQGQTLFIPTGWIHAVLTP
VDCLAFGGNFLHSLNIEMQLKAYEIEKRLSTADLFRFPNFETICWYVGKHILDIFRGLRE
NRRHPASYLVHGGKALNLAFRAWTRKEALPDHEDEIPETVRTVQLIKDLAREIRLVEDIF
QQNVGKTSNIFGLQRIFPAGSIPLTRPAHSTSVSMSRLSLPSKNGSKKKGLKPKELFKKA
ERKGKESSALGPAGQLSYNLMDTYSHQALKTGSFQKAKFNITGACLNDSDDDSPDLDLDG
NESPLALLMSNGSTKRVKSLSKSRRTKIAKKVDKARLMAEQVMEDEFDLDSDDELQIDER
LGKEKATLIIRPKFPRKLPRAKPCSDPNRVREPGEVEFDIEEDYTTDEDMVEGVEGKLGN
GSGAGGILDLLKASRQVGGPDYAALTEAPASPSTQEAIQGMLCMANLQSSSSSPATSSLQ
AWWTGGQDRSSGSSSSGLGTVSNSPASQRTPGKRPIKRPAYWRTESEEEEENASLDEQDS
LGACFKDAEYIYPSLESDDDDPALKSRPKKKKNSDDAPWSPKARVTPTLPKQDRPVREGT
RVASIETGLAAAAAKLAQQELQKAQKKKYIKKKPLLKEVEQPRPQDSNLSLTVPAPTVAA
TPQLVTSSSPLPPPEPKQEALSGSLADHEYTARPNAFGMAQANRSTTPMAPGVFLTQRRP
SVGSQSNQAGQGKRPKKGLATAKQRLGRILKIHRNGKLLL
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| BDBM50273469 |
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| n/a |
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| Name | BDBM50273469 |
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| Synonyms: | CHEMBL4126406 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26INO3 |
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| Mol. Mass. | 479.3512 |
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| SMILES | [I-].Cc1oc2ccccc2c1C(=O)c1ccc(OCCC[N+](C)(C)C)cc1 |
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| Structure | 
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