| Reaction Details |
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 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
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| Ligand | BDBM50008999 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_4180 (CHEMBL619245) |
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| IC50 | 2500±n/a nM |
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| Citation |  Malleron, JL; Roussel, G; Gueremy, G; Ponsinet, G; Robin, JL; Terlain, B; Tissieres, JM Penta- and hexadienoic acid derivatives: a novel series of 5-lipoxygenase inhibitors. J Med Chem33:2744-9 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyunsaturated fatty acid 5-lipoxygenase |
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| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
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| Synonyms: | Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 78082.31 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1432947 |
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| Residue: | 673 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDE
ELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLAR
DDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLN
YSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGC
NPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPC
THQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFH
IHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGL
FDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEA
IQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLT
VVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWH
LGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYY
YLSPDRIPNSVAI
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| BDBM50008999 |
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| n/a |
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| Name | BDBM50008999 |
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| Synonyms: | 5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihydro-pyrazol-3-one | 5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihydro-pyrazol-3-one( nafazatrom) | 5-Methyl-2-[2-(naphthalen-2-yloxy)-ethyl]-2,4-dihydro-pyrazol-3-one(nafazatrom) | CHEMBL8425 | Nafazatrom |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N2O2 |
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| Mol. Mass. | 268.3104 |
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| SMILES | Cc1cc(=O)n(CCOc2ccc3ccccc3c2)[nH]1 |
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| Structure | 
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