| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50274270 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1713978 (CHEMBL4124027) |
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| IC50 | 5334±n/a nM |
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| Citation |  Burmistrov, V; Morisseau, C; Pitushkin, D; Karlov, D; Fayzullin, RR; Butov, GM; Hammock, BD Adamantyl thioureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett28:2302-2313 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
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| Type: | Enzyme |
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| Mol. Mass.: | 62613.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34913 |
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| Residue: | 555 |
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| Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
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| BDBM50274270 |
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| n/a |
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| Name | BDBM50274270 |
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| Synonyms: | CHEMBL4128446 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H40N2S |
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| Mol. Mass. | 448.706 |
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| SMILES | S=C(NCCC12CC3CC(CC(C3)C1)C2)Nc1ccc(cc1)C12CC3CC(CC(C3)C1)C2 |TLB:4:5:8:12.11.10,19:22:25:29.28.27,THB:13:5:8:12.11.10,13:11:8:14.6.5,23:22:25.24.29:27,23:24:27:31.22.30,30:22:25:29.28.27,30:28:25:31.22.23,6:7:10:14.5.13,6:5:8.7.12:10| |
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| Structure | 
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