| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50274274 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1713978 (CHEMBL4124027) |
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| IC50 | 1248±n/a nM |
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| Citation |  Burmistrov, V; Morisseau, C; Pitushkin, D; Karlov, D; Fayzullin, RR; Butov, GM; Hammock, BD Adamantyl thioureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett28:2302-2313 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
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| Type: | Enzyme |
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| Mol. Mass.: | 62613.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34913 |
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| Residue: | 555 |
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| Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
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| BDBM50274274 |
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| n/a |
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| Name | BDBM50274274 |
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| Synonyms: | CHEMBL4125964 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H36N2S |
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| Mol. Mass. | 420.653 |
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| SMILES | S=C(Nc1ccc(cc1)C12CC3CC(CC(C3)C1)C2)NC12CC3CC(CC(C3)C1)C2 |TLB:19:20:23:27.26.25,6:9:12:16.15.14,THB:28:20:23:27.26.25,28:26:23:29.21.20,10:9:12.11.16:14,10:11:14:18.9.17,17:9:12:16.15.14,17:15:12:18.9.10,21:22:25:29.20.28,21:20:23.22.27:25| |
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| Structure | 
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