Reaction Details |
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Target | Cytochrome P450 11B2, mitochondrial |
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Ligand | BDBM50275531 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1714736 (CHEMBL4124785) |
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IC50 | 5.4±n/a nM |
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Citation | Sakakibara, R; Sasaki, W; Onda, Y; Yamaguchi, M; Ushirogochi, H; Hiraga, Y; Sato, K; Nishio, M; Egi, Y; Takedomi, K; Shimizu, H; Ohbora, T; Akahoshi, F Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2. J Med Chem61:5594-5608 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 11B2, mitochondrial |
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Name: | Cytochrome P450 11B2, mitochondrial |
Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
Type: | Protein |
Mol. Mass.: | 57582.15 |
Organism: | Homo sapiens (Human) |
Description: | P19099 |
Residue: | 503 |
Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
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BDBM50275531 |
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n/a |
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Name | BDBM50275531 |
Synonyms: | CHEMBL4128167 |
Type | Small organic molecule |
Emp. Form. | C13H10ClN3 |
Mol. Mass. | 243.692 |
SMILES | Clc1cc(ccc1-c1cnn2CCCc12)C#N |
Structure |
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