| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cytochrome P450 11B2, mitochondrial |
|---|
| Ligand | BDBM50275544 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1714736 (CHEMBL4124785) |
|---|
| IC50 | 2.2±n/a nM |
|---|
| Citation |  Sakakibara, R; Sasaki, W; Onda, Y; Yamaguchi, M; Ushirogochi, H; Hiraga, Y; Sato, K; Nishio, M; Egi, Y; Takedomi, K; Shimizu, H; Ohbora, T; Akahoshi, F Discovery of Novel Pyrazole-Based Selective Aldosterone Synthase (CYP11B2) Inhibitors: A New Template to Coordinate the Heme-Iron Motif of CYP11B2. J Med Chem61:5594-5608 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cytochrome P450 11B2, mitochondrial |
|---|
| Name: | Cytochrome P450 11B2, mitochondrial |
|---|
| Synonyms: | Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 57582.15 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P19099 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQG
YEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYR
QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNA
RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM
PRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELS
LEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATT
ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRP
ERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQED
IKMVYSFILRPGTSPLLTFRAIN
|
|
|
|---|
| BDBM50275544 |
|---|
| n/a |
|---|
| Name | BDBM50275544 |
|---|
| Synonyms: | CHEMBL4127675 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H14N6O |
|---|
| Mol. Mass. | 342.3541 |
|---|
| SMILES | Cc1cc(ccc1-c1cnn2C[C@@H](Cc12)Oc1ncc(cn1)C#N)C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
