| Reaction Details |
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 | Report a problem with these data |
| Target | Choline kinase |
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| Ligand | BDBM50166172 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1714829 (CHEMBL4124878) |
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| IC50 | 1750±n/a nM |
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| Citation |  Schiafino-Ortega, S; Baglioni, E; Pérez-Moreno, G; Marco, PR; Marco, C; González-Pacanowska, D; Ruiz-Pérez, LM; Carrasco-Jiménez, MP; López-Cara, LC 1,2-Diphenoxiethane salts as potent antiplasmodial agents. Bioorg Med Chem Lett28:2485-2489 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Choline kinase |
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| Name: | Choline kinase |
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| Synonyms: | 2.7.1.32 | Choline kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52197.43 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_118136 |
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| Residue: | 440 |
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| Sequence: | MESKICDPIGLDKNKFRKVEEENEENSKIVENGQMTYNDDLEMFTTIQLNQEIDIRKNPF
PLHMINQKNDIPLCAQEFSKLTDPLYIKKICLEKVHDWSRCNEDDVCVNQILSGLTNQLF
EVSIKEDTAIEYRITRRHVLFRIYGKDVDALYNPLSEFEVYKTMSKYRIAPLLLNTFDGG
RIEEWLYGDPLSIDDLKNKSILVGIANVLGKFHTLSRKRHLPEHWDKTPCVFKMMDRWRL
AVSNYKNLDKVTLDINKYIQESHKFLKFIKIYTQIENIANDIVFCHNDLQENNIMNTNKC
LRLIDFEYSGYNFLSADIANFFIETTIDYSYNAYPFFIINKKNYISYESRILFVTTYLSK
YLDDSTAASDQDIIDQFLEAIEVQALGLHLIWAFWSIIRGYQTKSYNEFDFFLYAKERLK
MYDEQKQYLMSKNIIKDYDD
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| BDBM50166172 |
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| n/a |
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| Name | BDBM50166172 |
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| Synonyms: | Bisquinolinium derivative | CHEMBL192986 |
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| Type | Small organic molecule |
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| Emp. Form. | C46H38Cl2N4 |
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| Mol. Mass. | 717.726 |
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| SMILES | C\[N+](c1ccc(Cl)cc1)=c1\ccn(Cc2ccc(cc2)-c2ccc(Cn3cc\c(=[N+](/C)c4ccc(Cl)cc4)c4ccccc34)cc2)c2ccccc12 |
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| Structure | 
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